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Literature summary extracted from

  • Hair, P.S.; Ward, M.D.; Semmes, O.J.; Foster, T.J.; Cunnion, K.M.
    Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b (2008), J. Infect. Dis., 198, 125-133.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.45 88000
-
 Western blotting Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.45 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.45 by size-exclusion chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.45 blood serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.45 complement component C3b + H2O
-
 Homo sapiens inactivated C3b + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.45 complement regulator factor I
-
 Homo sapiens
3.4.21.45 factor I
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.45 additional information clumping factor A is shed from the surface of Staphylococcus aureus and binds to factor I. Recombinant clumping factor A and the shed clumping factor A fragment increase factor I cleavage of C3b. Cofactor activity increases in a dose-dependent manner Homo sapiens